Rune Locations:
Light Rune - Chapter 3 - Given to you by a witch and her sister
Fire Rune - Chapter 4 - Obtained by defeating the Beguiler and his clown
Water Rune - Chapter 8 - Obtained by reuniting the lost brothers
Dark Rune - Chapter 10 - Obtained by reuniting the two children with their mother.
Health Tip:
When close to a mushroom ring, save your game, quit and reload to restore health.